Association of Genetic Variants with Lipoprotein Levels and Cardiovascular Risk1
نویسنده
چکیده
Background: Many studies have shown that a reduction in low-density lipoprotein cholesterol (LDL-C) is associated with lower risk of cardiovascular disease. It has been suggested that the reduction of cardiovascular risk is proportional to the reduction in LDL-C. However, cholesteryl ester transfer protein (CETP) inhibitors have not been shown to follow this pattern. These medications increase high-density lipoprotein cholesterol (HDL-C) and lower LDL-C, yet studies show no change in the reduction of risk of cardiovascular events. This raises question that the reduction in cardiovascular risk by lowering LDL-C may be dependent on the mechanism of which LDL-C is lowered.
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